Kratom contains over 25 alkaloids, so what are they and why do they make kratom so effective in so many areas. Here’s a list of the different Kratom Alkaloids with descriptions and resources to dig further if you wish. Is Kratom Safe? Here’s exactly what’s in a kratom leaf.
The Most Known Kratom Alkaloids:
Probably the most known and most active this kratom alkaloid is responsible for analgesic (pain killer), antitussive (capable of relieving or suppressing coughing), antidiarrheal (prevents diarrhea), adrenergic (activated by or capable of releasing epinephrine or an epinephrine like substance, especially in the sympathetic nervous system), antimalarial (preventing or relieving the symptoms of malaria). Believed to be one of the top two active alkaloids in kratom with 7-hydroxymitragynine being the other.
Mitragynine Depression Study
Another highly active kratom alkaloid, properties include analgesic (also known as a painkiller), antitussive (capable of relieving or suppressing coughing), antidiarrheal (used to prevent or treat diarrhea). Studies suggest that the opioid effect of kratom is mainly based on the activity of 7-hydroxymitragynine. It is very important to distinguish that no alkaloid in kratom is an actual opiate, only that they hit the opiate receptors. They do not have the dangerous side effects of true opiates such as affecting the respiratory system.
Cerebrocirculant (movement of blood through the network of blood vessels supplying the brain), antiaggregant (decrease platelet aggregation and inhibit blood clot formation), anti-adrenergic (at alpha-1), sedative, anticonvulsant, smooth muscle relaxer
Opioid antagonist (a receptor antagonist that acts on opioid receptors).
Calcium channel blocker.
Corynoxine A and B
Antioxidant, antiaggregant (decrease platelet aggregation and inhibit blood clot formation), antibacterial, antidiabetic, antihepatitic, anti-inflammatory, anti-leukemic, antimutagenic, antiperoxidant, antiviral, cancer preventative, alpha-amylase inhibitor
List of known Kratom Alkaloids:
|Ajmalicine (Raubasine)||Cerebrocirculant, antiaggregant, anti-adrenergic (at alpha-1), sedative, anticonvulsant, smooth muscle relaxer|
|Corynoxeine||Calcium channel blocker|
|Corynoxine A and B||Dopamine mediating anti-locomotives|
|(-)-Epicatechin||Antioxidant, antiaggregant, antibacterial, antidiabetic, antihepatitic, anti-inflammatory, anti-leukemic, antimutagenic, antiperoxidant, antiviral, cancer preventative, alpha-amylase inhibitor|
|9-Hydroxycorynantheidine||Partial opioid agonist|
|7-Hydroxymitragynine||Analgesic, antitussive, antidiarrheal; primary psychoactive in kratom|
|Mitragynine||Analgesic, antitussive, antidiarrheal, adrenergic, antimalarial, possible psychedelic (5-HT2A) antagonist|
|Mitraphylline||Vasodilator, antihypertensive, muscle relaxer, diuretic, anti-amnesic, possible immunostimulant|
|Paynantheine||Smooth muscle relaxer|
|Rhynchophylline||Vasodilator, antihypertensive, calcium channel blocker, antiaggregant, anti-inflammatory, antipyretic, anti-arrhythmic, antithelmintic|
|Speciociliatine||Weak opioid agonist|
|Speciogynine||Smooth muscle relaxer|
|Tetrahydroalstonine||Hypoglycemic, anti-adrenergic (at alpha-2)|