Kratom Alkaloids

Kratom contains over 25 alkaloids, so what are they and why do they make kratom so effective in so many areas. Here’s a list of the different Kratom Alkaloids with descriptions and resources to dig further if you wish.

The Most Known Kratom Alkaloids:

Kratom Alkaloids - Mitragynine

Mitragynine

Probably the most known and most active this kratom alkaloid is responsible for analgesic (pain killer), antitussive (capable of relieving or suppressing coughing), antidiarrheal (prevents diarrhea), adrenergic (activated by or capable of releasing epinephrine or an epinephrine like substance, especially in the sympathetic nervous system), antimalarial (preventing or relieving the symptoms of malaria). Believed to be one of the top two active alkaloids in kratom with 7-hydroxymitragynine being the other.
Other resources:
Wikipedia: Mitragynine
Mitragynine Depression Study

7-hydroxymitragynine

Another highly active kratom alkaloid, properties include analgesic (also known as a painkiller), antitussive (capable of relieving or suppressing coughing), antidiarrheal (used to prevent or treat diarrhea). Studies suggest that the opioid effect of kratom is mainly based on the activity of 7-hydroxymitragynine. It is very important to distinguish that no alkaloid in kratom is an actual opiate, only that they hit the opiate receptors. They do not have the dangerous side effects of true opiates such as affecting the respiratory system.

Other resources:
Wikipedia: 7-hydroxymitragynine
Clinical Test at Chiba University: Japan
Pharmacological Studies

Ajmalicine (Raubasine)

Cerebrocirculant (movement of blood through the network of blood vessels supplying the brain), antiaggregant (decrease platelet aggregation and inhibit blood clot formation), anti-adrenergic (at alpha-1), sedative, anticonvulsant, smooth muscle relaxer

Other resources:
Wikipedia: Ajmalicine

Corynantheidine (Rauhimbine)

Opioid antagonist (a receptor antagonist that acts on opioid receptors).

Other resources:
Wikipedia: Corynantheidine

Corynoxeine

Calcium channel blocker.

Corynoxine A and B

Dopamine mediators

(-) Epicatechin

Antioxidant, antiaggregant (decrease platelet aggregation and inhibit blood clot formation), antibacterial, antidiabetic, antihepatitic, anti-inflammatory, anti-leukemic, antimutagenic, antiperoxidant, antiviral, cancer preventative, alpha-amylase inhibitor

Other resources:
Wikipedia: Epicatechin
Phytochemicals: Epicatechin

List of known Kratom Alkaloids:

Ajmalicine (Raubasine) Cerebrocirculant, antiaggregant, anti-adrenergic (at alpha-1), sedative, anticonvulsant, smooth muscle relaxer
Corynantheidine Opioid antagonist
Corynoxeine Calcium channel blocker
Corynoxine A and B Dopamine mediating anti-locomotives
(-)-Epicatechin Antioxidant, antiaggregant, antibacterial, antidiabetic, antihepatitic, anti-inflammatory, anti-leukemic, antimutagenic, antiperoxidant, antiviral, cancer preventative, alpha-amylase inhibitor
9-Hydroxycorynantheidine Partial opioid agonist
7-Hydroxymitragynine Analgesic, antitussive, antidiarrheal; primary psychoactive in kratom
Isomitraphylline Immunostimulant, anti-leukemic
Isopteropodine Immunostimulant
Mitragynine Analgesic, antitussive, antidiarrheal, adrenergic, antimalarial, possible psychedelic (5-HT2A) antagonist
Mitraphylline Vasodilator, antihypertensive, muscle relaxer, diuretic, anti-amnesic, possible immunostimulant
Paynantheine Smooth muscle relaxer
Rhynchophylline Vasodilator, antihypertensive, calcium channel blocker, antiaggregant, anti-inflammatory, antipyretic, anti-arrhythmic, antithelmintic
Speciociliatine Weak opioid agonist
Speciogynine Smooth muscle relaxer
Speciophylline Anti-leukemic
Tetrahydroalstonine Hypoglycemic, anti-adrenergic (at alpha-2)